Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex
نویسندگان
چکیده
منابع مشابه
A nanocomplex of C60 fullerene with cisplatin: design, characterization and toxicity
The self-organization of C60 fullerene and cisplatin in aqueous solution was investigated using the computer simulation, dynamic light scattering and atomic force microscopy techniques. The results evidence the complexation between the two compounds. The genotoxicity of С60 fullerene, Cis and their complex was evaluated in vitro with the comet assay using human resting lymphocytes and lymphocyt...
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BACKGROUND Doxorubicin (Dox) is one of the most potent anticancer drugs, but its successful use is hampered by high toxicity caused mainly by generation of reactive oxygen species. One approach to protect against Dox-dependent chemical insult is combined use of the cytostatic drug with antioxidants. C60 fullerene has a nanostructure with both antioxidant and antitumor potential and may be usefu...
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The main aim of this work was to evaluate the effect of doxorubicin in complex with C60 fullerene (C60 + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C60 + Dox complex action. We found that volume of tumor from mice treated with the C60 + Dox complex was 1.4 times less than that in control untreated animals. ...
متن کاملPermeation of skin with (C60) fullerene dispersions
Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents ...
متن کاملOn Representation and Characterization of Fullerene C60
An operation on trivalent graphs leads from the truncated cube to buckminsterfullerene, and C60 is the only fullerene with disjoint pentagons which can be obtained by this method. The construction and the proof emphasize maximal independent sets that contains two fifths of vertices of trivalent graphs. In the case of C60 these sets define the structure of experimentally obtained bromofullerene ...
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ژورنال
عنوان ژورنال: Nanomaterials
سال: 2019
ISSN: 2079-4991
DOI: 10.3390/nano9111540